Which lipoprotein particle carries less cholesterol and is associated with a decreased risk of blood vessel blockage?

• A. Low Density Lipoprotein (LDL)
• B. Chylomicron
• C. High Density Lipoprotein (HDL)
• D. Very Low Density Lipoprotein (VLDL)

Answer: (C)

Lipoproteins vary in density and in how much cholesterol they carry. The densest particles, HDL, have a high protein content and relatively less cholesterol per particle. Their key job is reverse cholesterol transport: they scavenge cholesterol from arterial plaques and transport it back to the liver for disposal or reuse. This helps reduce plaque buildup in blood vessels and lowers the risk of blockage.

That’s why HDL is the best answer here: it carries less cholesterol overall compared with other major lipoproteins and is linked to a decreased risk of atherosclerosis and vessel blockage. In contrast, LDL delivers cholesterol to tissues and promotes plaque formation, while VLDL and chylomicrons are rich in triglycerides and are more associated with lipid delivery than protection.